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中华针灸电子杂志 ›› 2024, Vol. 13 ›› Issue (02) : 69 -72. doi: 10.3877/cma.j.issn.2095-3240.2024.02.006

综述

基于脑电的针灸效应机制研究进展
刘琪1, 涂娜1, 贾术永2, 郭义3, 王广军2,()   
  1. 1. 100700 北京,中国中医科学院针灸研究所;301617 天津中医药大学
    2. 100700 北京,中国中医科学院针灸研究所
    3. 301617 天津中医药大学
  • 收稿日期:2024-03-25 出版日期:2024-05-15
  • 通信作者: 王广军
  • 基金资助:
    中国中医科学院创新工程资质项目(CI2021A03511); 中央级公益性科研院所基本科研业务费专项资金资助(ZZ2023005)

Research progress on mechanism of acupuncture and moxibustion based on EEG analysis

Qi Liu1, Na Tu1, Shuyong Jia2, Yi Guo3, Guangjun Wang2,()   

  1. 1. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China; Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
    3. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • Received:2024-03-25 Published:2024-05-15
  • Corresponding author: Guangjun Wang
引用本文:

刘琪, 涂娜, 贾术永, 郭义, 王广军. 基于脑电的针灸效应机制研究进展[J]. 中华针灸电子杂志, 2024, 13(02): 69-72.

Qi Liu, Na Tu, Shuyong Jia, Yi Guo, Guangjun Wang. Research progress on mechanism of acupuncture and moxibustion based on EEG analysis[J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2024, 13(02): 69-72.

针灸疗法是补充和替代医学中被广泛使用的疗法之一,操作简便,安全性高,临床疗效较为显著。脑电图作为一种神经影像技术,具有较高的时间分辨率,可以实时监测脑功能活动,近年来逐渐被应用于针灸脑效应机制的研究。通过文献分析发现脑电的检测与分析主要应用于研究经穴效应特异性,探索不同穴位的针灸脑电响应特征;研究针灸效应的作用机制,探索生理状态下针灸的脑电响应特征与病理状态下针灸的脑电作用机制;研究针灸效应的影响因素,从脑电的角度分析不同的特异性或非特异性影响因素对针灸疗法的影响;研究针灸疗效的预测,探究使用脑电指标作为针灸预后的客观评价指标的可能。综述探讨脑电在针灸科学研究中的应用,为脑电在针灸疗法的科学研究与临床应用中提供证据。

Acupuncture is one of the widely used therapies within the realm of complementary and alternative medicine due to its ease of operation, safety and notable clinical effectiveness. Electroencephalogram (EEG) serves as a neuroimaging technique characterized by its ability to provide high temporal resolution. This technique enables the real-time monitoring of brain functional activities and has been increasingly employed in research to investigate the mechanism underlying the effects of acupuncture on the brain within recent years. Literature review revealed that the EEG detection and analysis are mainly employed to investigate the specificity of meridian and acupoint effects. This approach aims to explore the EEG response patterns associated with acupuncture at various acupoints as well as to examine the mechanism underlying the effect of acupuncture. Furthermore, the analysis could applied to elucidate the EEG response characteristics of acupuncture in both physiological state and pathological states; to study the determinants of acupuncture efficacy and assess the influence of various specific or non-specific factors on the acupuncture therapy from the EEG perspective; to study the prediction of acupuncture effectiveness and to explore the potential application of EEG markers as a quantitative assessment measure for predicting acupuncture prognosis. This study provides an overview of the application of EEG in the scientific research of acupuncture and provides evidence for the scientific research and clinical application of EEG in acupuncture therapy.

1
Han JSHo YS.Global trends and performances of acupuncture research [J].Neurosci Biobehav Rev201135(3):680-687.
2
吴云军,王华军,郑小飞.针灸治疗关节相关疾病的研究进展[J/OL].中华针灸电子杂志20209(1):28-32.
3
罗琼,王晓羽,米勇.针灸治疗颈肌劳损的临床研究进展[J].新疆中医药2022, 40(1):90-92.
4
Yuan SHuang CXu Y,et al.Acupuncture for lumbar disc herniation: Protocol for a systematic review and meta-analysis[J].Medicine (Baltimore)202099(9):e19117.
5
Hori ETakamoto KUrakawa S, et al. Effects of acupuncture on the brain hemodynamics[J]. Auton Neurosci2010157(1-2):74-80.
6
Zhang KYang H.Altered brain functional networks after Quchi (LI 11) acupuncture:An EEG analysis[J].Technology and Health Care202331(S1): 429-440.
7
Ingber LNunez PL.Neocortical dynamics at multiple scales: EEG standing waves, statistical mechanics,and physical analogs[J].Math Biosci2011229(2):160-173.
8
Muller-Putz GR.Electroencephalography[J]. Handb Clin Neurol2020, 168:249-262.
9
de Aguiar Neto FSRosa JLG.Depression biomarkers using non-invasive EEG:A review[J].Neurosci Biobehav Rev2019105:83-93.
10
尹涛,滕雨可,曾芳.针灸神经影像学研究现状与展望[J].生命科学2022, 34(5):517-524.
11
Zhao LChen JLiu CZ,et al.A review of acupoint specificity research in china: status quo and prospects[J].Evid Based Complement Alternat Med20122012:543943.
12
Choi KHKwon OSCho SJ,et al.Evaluating Acupuncture Point and Nonacupuncture Point Stimulation with EEG:A High-Frequency Power Spectrum Analysis[J].Evidence-Based Complementary and Alternative Medicine20162016:1-9.
13
Streitberger KSteppan JMaier C,et al.Effects of Verum Acupuncture Compared to Placebo Acupuncture on Quantitative EEG and Heart Rate Variability in Healthy Volunteers[J].The Journal of Alternative and Complementary Medicine200814(5):505-513.
14
Guo LWang YYu H,et al.Study of brain functional network based on sample entropy of EEG under magnetic stimulation at PC6 acupoint[J]. Biomed Mater Eng201424(1):1063-1069.
15
Wen JChen XYang Y,et al.Acupuncture Medical Therapy and its Underlying Mechanisms: A Systematic Review[J]. Am J Chin Med, 202149(1): 1-23.
16
高德强,张东友,崔炳南,等.针刺脑效应功能磁共振成像研究进展[J].中华中医药杂志201934(4):1328-1330.
17
Vickers AJCronin AMMaschino AC,et al.Acupuncture for chronic pain: individual patient data meta-analysis[J].Arch Intern Med2012172(19): 1444-1453.
18
黄强.中医针灸治疗痛症的研究进展[J].大众科技202123(4):105-107.
19
余东,孙晶,罗佳瑶,等.针灸治神在慢性疼痛治疗中的运用浅析[J].浙江中西医结合杂志202030(9):775-777.
20
Kim MSCho YCMoon JH,et al.A characteristic estimation of bio-signals for electro-acupuncture stimulations in human subjects[J]. Am J Chin Med200937(3):505-517.
21
Yu HWu XCai L,et al.Modulation of Spectral Power and Functional Connectivity in Human Brain by Acupuncture Stimulation[J].IEEE Transactions on Neural Systems and Rehabilitation Engineering2018, 26(5):977-986.
22
Yang SQiao YWang L,et al.Magnetic stimulation at acupoints relieves mental fatigue: An Event Related Potential (P300) study[J].Technol Health Care201725(S1):157-165.
23
Qi SY, Lin D, Lin LL, et al.Using Nonlinear Dynamics and Multivariate Statistics to Analyze EEG Signals of Insomniacs with the Intervention of Superficial Acupuncture[J].Evidence-Based Complementary and Alternative Medicine20202020:1-13.
24
Sarosiek ISong GSun Y,et al.Central and Peripheral Effects of Transcutaneous Acupuncture Treatment for Nausea in Patients with Diabetic Gastroparesis[J].J Neurogastroenterol Motil201723(2):245-253.
25
Liao FZhang CBian Z,et al.Characterizing heat-sensitization responses in suspended moxibustion with high-density EEG[J].Pain Med, 201415(8):1272-1281.
26
毛文超,刘保延,何丽云,等.关于针灸临床研究中安慰针刺对照设置的思考[J].中国针灸201333(4):367-371.
27
Yu HLi XLei X,et al.Modulation Effect of Acupuncture on Functional Brain Networks and Classification of Its Manipulation With EEG Signals[J].IEEE Transactions on Neural Systems and Rehabilitation Engineering, 201927(10):1973-1984.
28
Choi DHLee SLee IS,et al.The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study[J]. Mol Pain202218:17448069221128667.
29
Cabýoglu MT, Ergene N, Tan U. The mechanism of acupuncture and clinical applications[J].Int J Neurosci2006116(2):115-125.
30
Fan XHuang XZhao Y,et al.Predicting Prognostic Effects of Acupuncture for Depression Using the Electroencephalogram[J]. Evid Based Complement Alternat Med20222022:1381683.
31
贾琪,王广军.脑电微状态分析及其潜在应用可能性展望——针灸转化研究的一扇窗口[J].上海中医药杂志202256(1):7-11.
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