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Chinese Journal of Acupuncture and Moxibustion(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (01): 28-33. doi: 10.3877/cma.j.issn.2095-3240.2025.01.006

• Review • Previous Articles     Next Articles

Research progress on acupuncture treatment for Alzheimer′s disease based on the mechanism of brain-like lymphatic clearance mechanism

Ziyan Yuan1,2, Chunling Yao1,2, Jiangwei Shi1,2,   

  1. 1. Department of Acupuncture,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China
    2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China
  • Received:2024-03-20 Online:2025-02-15 Published:2025-03-20
  • Contact: Jiangwei Shi

Abstract:

The etiology and pathogenesis of Alzheimer′s disease are complex and still unclear,and modern medical research suggests that the onset of Alzheimer′s disease may be related to change in the cerebral microenvironment and abnormal clearance of metametabolic waste caused by aging,gheredity,autoimmunity,and environmental factors.Recent studies have found that the lymphoid system explains the immune pathways in the central nervous system and has become a new target for improving the brain microenvironment and cognitive disorders.This article reviews the mechanism of lymphoid system clearance and its possible influencing factors,and discusses the mechanism of acupuncture on lymphoid system and brain metabolism in combination with the meridian points of traditional Chinese medicine,so as to provide new ideas and methods for future modulation of lymphoid system in the treatment of Alzheimer′s disease.

Key words: Neuroglia-like lymphoid system, Alzheimer′s disease, Aquaporin 4, Acupuncture therapy

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