Migraine is a common and refractory disease in Western medicine, characterized by a prolonged course and frequent occurrence among young and middle-aged individuals. It is characterized by recurrent, unilateral pulsating headache. In contrast, acupuncture therapy has gained wider acceptance due to its high safety, solid efficacy, and few adverse effects. Based on the traditional Chinese medicine theory, Professor Ma Tieming has formed a unique pathogenesis view of "wind causes movement, and the liver is the viscus of wind", and put forward the innovative acupuncture theory of "fine-needle regulating the spirit, thick-needle regulating the form", which corresponds to the modern neurophysiological mechanism. By combining acupuncture and medicine and syndrome-differentiation and treatment, good curative effects have been achieved. Starting from the academic thought basis and clinical experience, this paper introduces Professor Ma Tieming's experience in treating migraine, providing new ideas for the modernization of traditional Chinese medicine and the treatment of migraine with the combination of acupuncture and medicine.