To observe the clinical effect of Gui Zhi Jia Ge Gen Tang combined with warming needle moxibustion on cervical vertigo and its influence on inflammatory factors IL- 6, hs-CRP, ET-1 and NO.

90 patients with cervical vertigo admitted to Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine from January 2019 to April 2022 were included and randomly divided into the control group and observation group with 45 cases each. The control group was treated with betahistine mesylate tablets, 6mg each time, three times a day. On the basis of the basic treatment, the observation group received warming needle moxibustion and Gui Zhi Jia Ge Gen Tang, warming needle moxibustion once every other day, and herbal medicine once a day. After 4 weeks, the cervical vertigo and functional score, systolic peak flow velocity (Vs) and mean blood flow velocity (Vm) levels of the anterior basilar artery and bilateral vertebral arteries, as well as the levels of hs-CRP, IL- 6, ET-1, and NO in two groups of patients before and after treatment were evaluate.

In the observation group, 16 cases were cured, 18 cases were significantly improved, 7 cases were effective, and 2 cases were ineffective, with a total effective rate of 95.35% (41/43); In the control group, 12 cases were cured, 9 cases were significantly improved, 15 cases were effective, and 8 cases were ineffective, with a total effective rate of 81.81% (36/44). The total effective rate of the observation group was significantly higher than that of the control group( χ²=3.914, P<0.05). After treatment, both groups showed significant improvement in dizziness, headache, neck and shoulder pain, daily life and work scores (observation group: t=-12.612, -16.809, -12.545, -15.902, all P<0.05; control group: t=-10.658, -8.691, -8.174, -11.681, all P<0.05); Compared with the control group, the observation group showed a significant increase in dizziness, headache, and neck and shoulder pain scores after treatment (t=-2.499, -4.279, -2.198, all P<0.05). After treatment, the Vs and Vm of the basilar and bilateral vertebral arteries in the observation group increased significantly(anterior basilar artery: t=-11.875, -63.50, P<0.05; bilateral vertebral artery: t=-37.346, -25.800, -25.699, -24.576, P<0.05); After treatment, the basal artery Vs and Vm in the control group increased significantly (t=-2.815, -10.823, all P<0.05). Compared with the control group, the Vs and Vm of the basilar and bilateral vertebral arteries in the observation group increased significantly after treatment (basilar artery: t=-3.022, -6.970, all P<0.05; bilateral vertebral artery: t=-8.073, -10.417, -6.356, -5.958, all P<0.05). After treatment, the levels of serum hs-CRP, IL- 6, and ET-1 in both groups decreased significantly after treatment, while the levels of NO increased significantly (observation group: t=15.549, 11.862, 18.102, -11.276, all P<0.05; control group: t=-8.767, -6.051, -9.565, -8.645, all P<0.05); Compared with the control group, the serum levels of hs-CRP, IL- 6, and ET-1 in the observation group decreased significantly after treatment, while the levels of NO increased significantly (t=4.177, 3.925, 6.110, -4.051, all P<0.05).

Gui Zhi Jia Ge Gen Tang combined with warming needle moxibustion can effectively improve the clinical symptoms of cervical vertigo. The mechanism may be related to decreasing serum inflammatory factors hs-CRP and IL- 6, in order to relieve muscle tension, and increasing NO synthesis, reducing ET release to improve vascular endothelial blood supply.