Professor Guo Yi proposed the "Four-Unblocking Method" for treating nonspecific low back pain (NSLBP), which consists acupuncture, cupping, tuina (Chinese therapeutic massage), and bone-setting. With the integration of these four techniques as its core, this method is rooted in the traditional Chinese medicine (TCM) theories of "pain from obstruction" (butong ze tong) and "pain from malnourishment" (burong ze tong), while also incorporating the meridian theory and the holistic concept of TCM. Through the combined application of acupuncture, cupping, tuina, and bone-setting, it functions to dredge the meridians, regulate qi and blood, release tense muscles and skin, and realign the muscles and bones. The specific procedures are as follows: first, using warming acupuncture technique to unblock the Du meridian and relieve pain; second, employing cupping therapy in the sequence of "flush cupping, moving cupping and short-duration retained cupping" to regulate qi and blood; third, Gentle and mild tuina and bone-setting manipulations are used to relax the muscular texture, soothe the tendons, and realign the bones. In clinical practice, the application of the "Four Unblocking Method" in treating NSLBP can significantly relieve pain symptoms and restore limb movement function. This treatment protocol emphasizes individualized design, conducting comprehensive treatment based on the etiological factors and pathogenesis characteristics of different patients. It has demonstrated remarkable clinical efficacy and possesses considerable promotion value.