近年来针药并用在膝骨关节炎（KOA）治疗中不断突破传统的联合方式，从针刺配合中药内服或外治逐步发展出电针导药、纳米微针、化学载药针具等多种针药联合技术，进一步提升了药物在患病部位的聚集浓度和作用时间。同时，针药并用体现了中医辨证个体化应用方案，表现出更好的镇痛、抗炎及软骨保护作用。针药并用在治疗KOA中发挥的缓解疼痛、改善关节功能、抑制炎症反应及延缓关节退变作用均优于单一针刺或药物的治疗方案，且新兴针药联合技术将有望推动针药并用在KOA治疗中的精准化和规范化发展。

In recent years, the combination of acupuncture and medication in the treatment of knee osteoarthritis (KOA) has continuously broken through traditional joint methods. From acupuncture combined with oral administration of traditional Chinese medicine (TCM) and external TCM therapy, a variety of combined acupuncture-medication technologies have been gradually developed, such as electroacupuncture-guided drug delivery, nano-microneedles, and chemical drug-loaded acupuncture instruments. These technologies have further increased the concentration of drugs accumulated at the lesion site and prolonged their action time.Meanwhile, the combination of acupuncture and medication, integrated with TCM syndrome differentiation, has demonstrated individualized application schemes, showing better effects in analgesia, anti-inflammation, and cartilage protection. Studies have shown that, in the treatment of KOA, the combined use of acupuncture and medication is superior to single acupuncture or single medication in relieving pain, improving joint function, inhibiting inflammatory responses, and delaying joint degeneration. Moreover, emerging combined acupuncture-medication technologies are expected to promote the development of precision and standardization in the application of acupuncture-medication combination for KOA treatment.