探讨电针治疗首发抑郁症的临床疗效。

选择2011年5月至2012年5月在新疆医科大学第一附属医院临床心理科住院治疗的首发抑郁症患者101例，按照随机数字法分为针药组(51例，其中男21例，女30例)和单纯药物组(50例，男23例，女27例)。单纯药物组仅服用帕罗西汀药物，针药组在服用帕罗西汀药物的基础上合并电针治疗(每日电针1次，每周治疗6次，共治疗4周)，采用重复测量的单因素方差分析，比较2组患者治疗前、1周末、2周末及4周末汉密尔顿抑郁量表(HMAD)量表总分及各因子分的差异。

两组在总分、迟缓和绝望感因子疗效上比较差异有统计学意义(F＝6.234、9.344、14.245，P均<0.05)；不同时间点上疗效比较，1周末2组在焦虑躯体化及睡眠障碍因子上差异有统计学意义(t＝－3.042、－3.349，P均<0.05)，2周末两组在总分、认知障碍、迟缓及绝望感因子分上差异有统计学意义(t＝5.888、－3.632、－2.835、－4.666，P均<0.05)，4周末两组在总分、焦虑躯体化、认知障碍、迟缓、绝望感因子分上差异有统计学意义(t＝－4.166、－4.047、－4.047、－7.484、－8.558，P均<0.05)。

合并电针治疗首发抑郁症可改善抑郁症患者的临床症状群。

To explore the clinical efficacy of electroacupuncture in the treatment of first-episode depression.

101 patients with first-episode depression who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from May 2011 to May 2012 were selected. According to the random number method, they were divided into acupuncture group (51 cases, including 21 males and 30 females), and the pure drug group (50 cases, 23 males and 27 females). The pure drug group was only treated with paroxetine, and the acupuncture group was combined with electroacupuncture on the basis of paroxetine (electroacupuncture 1 time/day, 6 days per week, and 4 weeks in total), and the changes of the HAMD scores of the patients in the two groups after 1 week, 2 weeks and 4 weeks were observed by one-way repeated measures ANOVA.

The differences in the factor scores of the HAMD total scores, retardation and hopelessness between the two groups were statistically significant (F=6.234, 9.344, 14.245, all P<0.05); the effect comparison at different time points, There were statistically significant differences in factor scores of somatic anxiety, cognitive impairment, and insomnia between the two groups after 1 week t=-3.042, -3.349, all P<0.05), The differences in HAMD total scores, and the factor scores of cognitive impairment, retardation and hopelessnes between the two groups after 2 weeks were statistically significant(t=5.888, -3.632, -2.835, -4.666, all P<0.05), There were statistically significant differences in HAMD total scores, and the factor scores of somatic anxiety, cognitive impairment, retardation and hopelessness between the two groups after 4 weeks(t=4.166, 4.047, 4.047, 7.484, 8.558, all P<0.05).

The combination of electroacupuncture therapy and drug can significantly improve the clinical symptoms of most patients with depression.