目的

研究温阳散神阙灸联合化疗方案治疗恶性腹水的近期疗效及提高生活质量的作用。

方法

选择2014年1月至2015年9月安徽中医药大学第二附属医院肿瘤科收治的符合纳入标准的腹腔积液患者37例。将37例患者按照抽签法随机分为治疗组12例、阴性对照组12例、阳性对照组13例。治疗组：在阳性对照组治疗基础上联合温阳散神阙灸。观察记录3组患者治疗前、第28天的腹水量、远期生活质量评估（KPS）评分；阴性对照组：采用腹腔引流积液；阳性对照组：在阴性对照组治疗基础上行腹腔灌注顺铂40 mg/m²，第1天和第7天各1次。各组患者入组前KPS评分为计量资料，并采用单因素方差分析；腹水疗效、KPS评分为计数资料采用确切概率法检验。

结果

治疗组腹水疗效有效10例，无效2例，总有效率为83.33%（10/12）；阴性对照组有效2例，无效10例，总有效率16.67%（2/12）；阳性对照组有效8例，无效5例，总有效率61.54%（8/13）。治疗组总改善10例，无改善2例，总改善率为83.33%（10/12），阴性对照组总改善4例，无改善8例，总改善率为33.33%（4/12），阳性对照组总改善9例，无改善4例，总改善率为69.23%（9/13）。治疗组腹水疗效、KPS评分均优于阴性对照组，差异均有统计学意义（x²=10.667、6.171，P均＜0.05）。

结论

温阳散神阙灸联合化疗方案治疗恶性腹水有一定的控制作用，且能够改善患者的生活质量，为腹水患者姑息治疗提供有效途径。

Objective

The aim of this study is to evaluate the curative efficacy and role of improving the quality of life in the treatment of malignant ascites with ShenQue（RN8）moxibustion of WenYangSan in combination with chemotherapy.

Methods

A total of 37 cases of ascites treated in the department of oncology，the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine were included in this study and randomly assigned into three groups：12 cases in negative control group received the abdominal cavity drainage，12 cases in positive control group received the abdominal cavity drainage and cisplatin（DDP）40 mg/m²，and 13 cases in study group received the abdominal cavity drainage and DDP 40 mg/m² combined with ShenQue（RN8）moxibustion of WenYangSan.The volume of ascites and long-term quality of life assessment（KPS）score were observed and recorded before and 28-day after treatment.Values of KPS score before being into groups were considered as measurement data，and were analyzed by single-factor analysis of variance.The curative effect and KPS score of ascites were counting data and were analysed by exact probability method.

Results

In study group，10 cases were effective，2 cases were ineffective，and the total effective rate was 83.33%（10/12）.In negative control group，2 cases were effective，10 cases were invalid，and the total effective rate was 16.67%（2/12）.In positive control group，8 cases were effective，5 cases ineffective，and the total effective rate was 61.54%（8/13）.In study group，10 cases were totally improved，2 cases were no improvement，and the total improvement rate was 83.33%（10/12）.In negative control group，4 cases were totally improved，8 cases were without improvement，and the total improvement rate was 33.33%（4/12）.In positive control group，9 cases were totally improved，4 cases showed no improvement，and the total total improvement rate was 69.23%（9/13）.The curative effect of ascites and quality of life was much better in study group than those of negative control group，the difference was statistically significant（x²=10.667，6.171，P＜0.05）.

Conclusion

ShenQue（RN8）moxibustion of WenYangSan in combined with chemotherapy for malignant ascites has certain control effect，and can improve the patient's quality of life，providing effective ways for palliative care in patients with ascites.