Abstract:
Objective
This study aimed to evaluate the clinical effects and safety of Hunyuan moxibustion in treating diarrhea-predominant irritable bowel syndrome （ IBS-D） with Spleen-Kidney Yang deficiency.
Methods
A total of 60 IBS-D patients with Spleen-Kidney Yang deficiency，who visited the Acupuncture Department and Gastroenterology Department of Nanchang Hongdu Hospital of Traditional Chinese Medicine （TCM） from March 2021 to March 2023 were recruited. Participants were randomly divided into Group I （treated with moxibustion first and then western medicine，30 cases） and Group II （treated with western medicine first and then moxibustion，30 cases）. This study adopted a randomized crossover design，in which each participant received both treatments. Hunyuan moxibustion was administered once daily，five times per week，for two weeks. Western medicine consisted of oral pinaverium bromide tablets （one tablet，three times per day，for two weeks）. A two-week washout period was set between the two treatment phases.When conducting the result statistics and analysis，they were respectively named as the Hunyuan moxibustion group and the western medicine group. Primary outcomes included symptom scores and TCM syndrome scores，assessed before and after treatment. The clinical efficacy and safety of the interventions were also evaluated.
Results
There were statistically significant differences in symptom scores and TCM syndrome scores between the two groups after treatment （F ＝ 24.963，8.522，24.049，27.434，23.946，12.992，371.200，P＜0.05）. In the first treatment stage，the total effective rate of the Hunyuan moxibustion group was 86.7% （26/30），while that of the western medicine group was 60.0% （18/30）. There was a statistically significant difference in the total effective rate between the two groups （χ2 ＝5.455，P ＜0.05）. In the second treatment stage，the total effective rate of the Hunyuan moxibustion group was 83.3% （25/30），while that of the western medicine group was 43.3% （13/30）. There was a statistically significant difference in the total effective rate between the two groups （χ2 ＝10.335， P ＜0.05）.
Conclusion
Hunyuan moxibustion is an effective and safe treatment for IBS-D with Spleen-Kidney Yang deficiency，demonstrating superior efficacy compared to western medicine. It holds promise for clinical application and further research.
Key words:
Irritable bowel syndrome,
Diarrhea,
Hunyuan moxibustion
Jiwei Wan, Hui Huang, Liang Zhou, Xiaoming Jiang, Guolong Wei, Xiuwu Hu. Hunyuan moxibustion for diarrhea-predominant irritable bowel syndrome with spleen-kidney Yang deficiency： a randomized crossover trial[J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2025, 14(02): 45-49.