Correlation between apolipoprotein E gene polymorphism and Alzheimer′s disease syndrome type in traditional Chinese medicine

doi:10.3877/cma.j.issn.2095-3240.2020.04.005

Abstract

Abstract:

With the deepening of the research on the role of apolipoprotein E gene(ApoE) polymorphism in the pathogenesis of Alzheimer′s disease (AD), and the preliminary development of the study on the nature of traditional Chinese medicine(TCM) syndrome of AD at the gene level, the correlation between gene polymorphism and TCM syndrome has been gradually verified. Analyzing the occurrence and development of the disease from this point of view can provide new ideas for the diagnosis and treatment of the disease. This article reviews the literature on the role of ApoE gene polymorphism in the pathogenesis of AD and its correlation with TCM syndromes of AD in recent years, so as to provide new ideas and intervention methods for TCM prevention and treatment of AD, and may provide micro basis for TCM syndrome classification.

Key words: Alzheimer disease, Symptom complex, Genes, Polymorphism, single nucleotide

Yunchen Xu, Liaoyao Wang, Jian Pei. Correlation between apolipoprotein E gene polymorphism and Alzheimer′s disease syndrome type in traditional Chinese medicine[J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2020, 09(04): 142-145.

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References 34

1	Kelley AS, Mcgarry K, Gorges R, et al. The burden of health care costs for patients with dementia in the last 5 years of life[J]. Annals of Internal Medicine, 2015, 163(10): 729-736.
2	阿尔茨海默病中医诊疗联合共识小组. 阿尔茨海默病的中医诊疗共识[J]. 中国中西医结合杂志，2018，38(5)：523-529.
3	程蕊，李玺，王娟，等．载脂蛋白E基因多态性与阿尔茨海默病相关性的Meta分析[J]．实用老年医学，2018，32(3)：263-267.
4	Mahley R. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology[J]. Science, 1988，240(4852)：622-630.
5	Yamazaki Y, Zhao N, Caulfield TR, et al. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies[J]．Nat Rev Neurol, 2019，15(9)：501-518.
6	Casey CS, Atagi Y, Yamazaki Y, et al. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway[J]. J Biol Chem, 2015，290(22)：14208-14217.
7	Wolk DA, Dickerson BC. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer’s disease[J]. Proc Natl Acad Sci USA，2010，107(22)：10256-10261.
8	Ossenkoppele R, Cohn-Sheehy BI, La Joie R, et al. Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer′s disease[J]. Hum Brain Mapp，2015，36(11)：4421-4437.
9	Gonneaud J, Arenaza-Urquijo EM, Fouquet M, et al. Relative effect of APOEε4 on neuroimaging biomarker changes across the lifespan[J]. Neurology, 2016，87(16)：1696-1703.
10	Serrano-Pozo A, Qian J, Monsell SE, et al. APOEε2 Is Associated With Milder Clinical and Pathological Alzheimer’s Disease[J]. Annals of Neurology, 2015，77(6)：917-929.
11	Hashimoto T, Serrano-Pozo A, Hori Y, et al. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide[J]. Journal of Neuroscience, 2012，32(43)：15181-15192.
12	Garai K, Verghese PB, Baban B, et al. The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation[J]. Biochemistry, 2014，53(40)：6323-6331.
13	Jiang T, Chang RC, Rosenmann H，et al. Advances in Alzheimer′s disease: from bench to bedside[J]．Biomed Res Int，2015：202676.
14	Ossenkoppele R, Schonhaut DR, Schöll M, et al. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease[J]. Brain, 2016, 139(Pt 5)：1551-1567.
15	Farfel JM, Yu L, De Jager PL, et al. Association of APOE with tau-tangle pathology with and without beta-amyloid[J]. Neurobiology of Aging, 2016，37：19-25.
16	Shi Y, Yamada K, Liddelow SA, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy[J]. Nature, 2017，549(7673): 523-527.
17	Niklas M, Rik O, Ruben S, et al. Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study[J]. Alzheimer′s Research & Therapy, 2018, 10(1)：77.
18	Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease[J]. Nature Reviews Neuroscience, 2015，16(6)：358-372.
19	Nazem A, Sankowski R, Bacher M, et al. Rodent models of neuroinflammation for Alzheimer’s disease[J]. J Neuroinflammation，2015，12：74.
20	Vitek MP, Brown CM, Colton CA. APOE genotype-specific differences in the innate immune response[J]. Neurobiology of aging, 2009, 30(9)：1350-1360.
21	Bonham LW, Desikan RS, Yokoyama JS. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease[J]. Acta Neuropathologica Communications，2016，4(1)：65.
22	侯江淇，郭蕾，张俊龙. 阿尔茨海默病中医辨治探析[J]. 辽宁中医杂志，2017，44(2)：44- 46.
23	尹龙，田金洲，时晶. 阿尔茨海默病的中医病机探讨[J]. 吉林中医药，2011，31(6)：495- 497.
24	张学凯，时晶，倪敬年，等. 阿尔茨海默病证候级联假说探讨[J]. 中医杂志，2019，60(9)：741-744.
25	时晶，倪敬年，魏明清，等. 阿尔茨海默病证候变化与认知结局的关联性[J]. 北京中医药大学学报，2017，40(4)：339-343.
26	Young AI, Benonisdottir S, Przeworski M, et al. Deconstructing the sources of genotype-phenotype associations in humans[J]. Science，2019，365(6460)：1396-1400.
27	Baselmans BML, Jansen R, Ip HF, et al. Multivariate genome-wide analyses of the well-being spectrum[J]. Nat Genet, 2019，51(3)：445- 451.
28	梁逸强，王佑华，周端．心脑血管相关疾病中医证候与基因多态性相关性的研究进展[J]中华中医药学刊，2011, 29(2)：286-288.
29	姚雪婷，梅应兵，孙勤国，等．老年健忘中医证型分布规律及与ApoE基因相关性[J]．中国老年学杂志，2020, 40(6)：1281-1284.
30	武峻艳，王杰. 从中医证候谈载脂蛋白E与阿尔茨海默病的相关性[J]. 陕西中医，2019, 40(8)：1109-1111.
31	李建橡，马晓聪，郑景辉，等. 痰瘀证候与载脂蛋白E基因多态性的meta分析[C]. 第九次全国中西医结合诊断学术研讨会论文集，2015, 334-339.
32	宋剑南，陈杲. 论载脂蛋白E及其基因多态性与中医痰瘀证候的关系[J]. 中国中医基础医学杂志，2002, 8(12)：893- 895.
33	胡慧，王平，孔明望，等. 阿尔茨海默病模型大鼠Tau蛋白异常磷酸化表达及补肾化痰法的干预作用[J]. 时珍国医国药，2010，21(10)：2681-2683.
34	苏芮，韩振蕴，范吉平，等. "毒损脑络"理论在阿尔茨海默病中医研究领域中的意义[J]. 中医杂志，2011，52(16)：1370-1371.

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