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中华针灸电子杂志 ›› 2026, Vol. 15 ›› Issue (01) : 43 -46. doi: 10.3877/cma.j.issn.2095-3240.2026.01.007

综述

针刺治疗原发性高血压的磁共振成像临床研究进展
魏晓雅1,2, 王旭3, 蒋馨源3, 杨娜娜1,2, 王泽一1,2, 屠建锋1,2,(), 刘存志1,2   
  1. 1 100029 北京中医药大学针灸推拿学院
    2 100029 北京中医药大学国际针灸创新研究院
    3 100029 北京中医药大学生命科学学院
  • 收稿日期:2025-10-25 出版日期:2026-02-15
  • 通信作者: 屠建锋
  • 基金资助:
    国家自然科学基金重点项目(82330126)

Clinical research progress in magnetic resonance imaging for acupuncture treatment of essential hypertension

Xiaoya Wei1,2, Xu Wang3, Xinyuan Jiang3, Nana Yang1,2, Zeyi Wang1,2, Jianfeng Tu1,2,(), Cunzhi Liu1,2   

  1. 1 School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China
    2 International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing 100029, China
    3 School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2025-10-25 Published:2026-02-15
  • Corresponding author: Jianfeng Tu
引用本文:

魏晓雅, 王旭, 蒋馨源, 杨娜娜, 王泽一, 屠建锋, 刘存志. 针刺治疗原发性高血压的磁共振成像临床研究进展[J/OL]. 中华针灸电子杂志, 2026, 15(01): 43-46.

Xiaoya Wei, Xu Wang, Xinyuan Jiang, Nana Yang, Zeyi Wang, Jianfeng Tu, Cunzhi Liu. Clinical research progress in magnetic resonance imaging for acupuncture treatment of essential hypertension[J/OL]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2026, 15(01): 43-46.

针刺治疗原发性高血压已取得良好临床疗效,但其降压作用的中枢神经机制尚需深入阐明。磁共振成像技术为此提供了客观的神经影像学依据,有助于探讨高血压相关脑机制及针刺干预的中枢作用路径。系统梳理并总结以下三方面内容:原发性高血压患者脑功能与结构的异常改变,针刺治疗高血压的影像学研究进展,以及自主神经系统相关脑区在针刺降压中的作用机制。基于现有神经影像学证据,进一步归纳了与针刺降压效应相关的脑区,并对当前研究的局限性进行分析,以期为深入揭示针刺治疗高血压的中枢机制、优化研究设计提供参考。

Acupuncture has achieved favorable clinical efficacy in the treatment of essential hypertension (EH), but the central nervous system mechanism underlying its antihypertensive effect remains to be further elucidated. Magnetic resonance imaging (MRI) technology provides objective neuroimaging evidence, facilitating the exploration of hypertension-related cerebral mechanisms and the central action pathways of acupuncture intervention. This article systematically combs and summarizes three core aspects: abnormal changes in brain function and structure in patients with EH, advances in MRI-based imaging research on acupuncture for EH, and the mechanism of action of brain regions associated with the autonomic nervous system in acupuncture-induced blood pressure reduction. Based on existing neuroimaging evidence, this review further concludes the key brain regions correlated with the antihypertensive effect of acupuncture, and analyzes the limitations of current studies—such as small sample sizes, inconsistent acupuncture protocols, and short-term follow-up duration. It aims to provide a reference for in-depth revelation of the central mechanism of acupuncture in treating EH and optimization of future research designs.

1
van Oort SBeulens JWJvan Ballegooijen AJ,et al. Association of cardiovascular risk factors and lifestyle behaviors with hypertension:a mendelian randomization study[J]. Hypertension202076(6):1971-1979.
2
Mills KTStefanescu AHe J. The global epidemiology of hypertension[J]. Nat Rev Nephrol202016(4):223-237.
3
Zhang MShi YZhou B,et al. Prevalence,awareness,treatment,and control of hypertension in China,2004-18:findings from six rounds of a national survey[J]. BMJ2023380:e071952.
4
中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2022概要[J]. 中国循环杂志202338(6):583-612.
5
徐寒冰,牛琳琳,温鑫,等. 针刺联合循经刮痧治疗原发性高血压的疗效观察及对24 h动态血压的影响[J]. 上海针灸杂志202342(5):459-465.
6
张赛,杨丽娟,张菊,等. 天柱透刺风池治疗原发性高血压病肝阳上亢证的临床观察[J]. 中医临床研究202214(13):66-69.
7
郑婕,赖新生,李景,等. 通元针法对肝阳上亢型原发性高血压症状评分、血脂水平的随机对照研究[J]. 时珍国医国药202233(1):141-144.
8
陆敏红,黄国圣,冯曼莎. 针刺联合耳穴贴压对原发性高血压患者动态血压及血压变异性指标的影响[J]. 长春中医药大学学报202137(6):1356-1359.
9
Fan MDai GLi R,et al. Efficacy of acupuncture in the treatment of essential hypertension:an overview of systematic reviews and Meta-analyses[J]. Cardiovasc Ther20232023:2722727.
10
Zhou MBu HWang D,et al. An overview of systematic reviews:acupuncture in the treatment of essential hypertension[J]. Int J Gen Med202215:8093-8109.
11
刘海华,王莹莹,高海波,等. 针灸治疗高血压病选穴规律文献研究[J]. 中医杂志201455(12):1055-1058.
12
韩侨宇,梁汉生. 针刺降压机制的研究进展[J]. 针刺研究202146(8):700-706.
13
Li JSun MYe J,et al. The Mechanism of acupuncture in treating essential hypertension:a narrative review[J]. Int J Hypertens20192019:8676490.
14
王婧,牛舰霏,李冠会,等. 针刺治疗原发性高血压病机制的研究概况[J]. 中国针灸201939(2):224-228.
15
王松涛,李艳伟,赵亚丹,等. 针刺治疗心血管疾病疗效及其中枢自主神经机制概述[J]. 山东中医杂志202241(7):795-800.
16
刘苑雅,孙佳盼,陶军. 针灸防治原发性高血压现代生物学机制研究进展[J]. 中西医结合心脑血管病杂志202220(3):472-476.
17
Bu LHuo CXu G,et al. Alteration in brain functional and effective connectivity in subjects with hypertension[J]. Front Physiol20189:669.
18
Carnevale LMaffei ALandolfi A,et al. Brain functional magnetic resonance imaging highlights altered connections and functional networks in patients with hypertension[J]. Hypertension202076(5):1480-1490.
19
McIntosh RCLobo JDYang A,et al. Brainstem network connectivity with mid-anterior insula predicts lower systolic blood pressure at rest in older adults with hypertension[J]. J Hum Hypertens202135(12):1098-1108.
20
马俊怡. 高血压患者大脑的结构/功能MRI改变[J]. 中风与神经疾病杂志202037(6):502-504.
21
Suzuki HGao HBai W,et al. Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension[J]. PLoS One201712(11):e0187600.
22
George KMMaillard PGilsanz P,et al. Association of early adulthood hypertension and blood pressure change with late-life neuroimaging biomarkers[J]. JAMA Netw Open20236(4):e236431.
23
Rim DDawood TFatouleh R,et al. Regional structural differences in the brain related to high blood pressure[J]. J Hypertens202543(9):1570-1581.
24
申陈镇,徐惠. 高血压与脑白质高信号相关性研究进展[J]. 医学影像学杂志202434(7):128-130,135.
25
秦银银,许建铭,朱建兵,等. 基于多模态MRI探讨高血压相关脑体积及脑白质信号改变的临床研究[J]. 磁共振成像202415(8):90-96.
26
Zou QHZhu CZYang Y,et al. An improved approach to detection of amplitude of low-frequency fluctuation(ALFF)for resting-state fMRI:fractional ALFF[J]. J Neurosci Methods2008172(1):137-141.
27
Zhang JLyu TYang Y,et al. Acupuncture at LR3 and KI3 shows a control effect on essential hypertension and targeted action on cerebral regions related to blood pressure regulation:a resting state functional magnetic resonance imaging study[J]. Acupunct Med202139(1):53-63.
28
Liao DGuo ZPTang LR,et al. Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension:a resting-state functional magnetic resonance imaging study[J]. Hypertens Res202346(5):1311-1325.
29
Wang YZheng YQu S,et al. Cerebral targeting of acupuncture at combined acupoints in treating essential hypertension:an rs-fMRI study and curative effect evidence[J]. Evid Based Complement Alternat Med20162016:5392954.
30
Zheng YZhang JWang Y,et al. Acupuncture decreases blood pressure related to hypothalamus functional connectivity with frontal lobe,cerebellum,and insula:a study of instantaneous and short-term acupuncture treatment in essential hypertension[J]. Evid Based Complement Alternat Med20162016:6908710.
31
Chen HDai JZhang X,et al. Hypothalamus-related resting brain network underlying short-term acupuncture treatment in primary hypertension[J]. Evid Based Complement Alternat Med20132013:808971.
32
尹涛,何昭璇,马培宏,等. 针刺功能磁共振成像研究任务设计方法述评[J]. 中华中医药学刊201937(7):1657-1660.
33
曹丹娜,王丰,张帆,等. 应用功能磁共振技术分析针刺太溪穴的降压机制[J]. 中国老年学杂志201535(15):4314-4316.
34
孙曌,沈巍,王小龙,等. 捻针及假针刺刺激太冲穴对原发性高血压患者的脑功能磁共振成像研究[J]. 中国针灸201434(12):1191-1195.
35
李胜南,李晓陵,于苗苗,等. 针刺太冲穴脑效应机制功能性磁共振成像研究进展[J]. 辽宁中医药大学学报202527(8):73-77.
36
Macefield VGHenderson LA. Identification of the human sympathetic connectome involved in blood pressure regulation[J]. Neuroimage2019202:116119.
37
Li YYLiu JPShi SF,et al. Acupuncture with twirling reinforcing and reducing manipulation shows a control of hypertension and regulation of blood pressure-related target brain regions in spontaneously hypertensive rat:a preliminary resting-state functional MRI study[J]. Front Neurosci202317:1161578.
38
Liu JPLi YYYang KZ,et al. Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats:A preliminary resting-state functional magnetic resonance imaging study[J]. Front Neurosci202317:1129688.
39
Uddin LQNomi JSHébert-Seropian B,et al. Structure and function of the human insula[J]. J Clin Neurophysiol201734(4):300-306.
40
Li YWLi WWang ST,et al. The autonomic nervous system:a potential link to the efficacy of acupuncture[J]. Front Neurosci202216:1038945.
41
Longhurst J. Acupuncture's cardiovascular actions:a mechanistic perspective[J]. Med Acupunct201325(2):101-113.
42
季淑梅,刘鹏,李围. 血压的中枢调节通路[J]. 实用医学杂志201127(17):3241-3242.
43
李宏宝. 头端延髓腹外侧区与原发性高血压[J]. 中华高血压杂志201119(10):917-919.
44
范浩,田中雪,马思明,等. 氧化应激-内质网应激-自噬在高血压延髓头端腹外侧区的作用及针刺干预机制研究进展[J]. 中华中医药杂志202136(7):4128-4131.
45
Wang XRYang JWJi CS,et al. Inhibition of NADPH oxidase-dependent oxidative stress in the rostral ventrolateral medulla mediates the asntihypertensive effects of acupuncture in spontaneously hypertensive rats[J]. Hypertension2018, 71(2):356-365.
46
Wang XLi JLWei XY,et al. Psychological and neurological predictors of acupuncture effect in patients with chronic pain:a randomized controlled neuroimaging trial[J]. Pain2023164(7):1578-1592.
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