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中华针灸电子杂志 ›› 2025, Vol. 14 ›› Issue (04) : 147 -152. doi: 10.3877/cma.j.issn.2095-3240.2025.04.003

重点专题:针灸治疗脑病·综述

针刺干预卒中后失语的多组学机制研究:进展与展望
邓士哲, 卓碧芳, 司尚坤, 孙淳, 孟智宏()   
  1. 300381 天津中医药大学第一附属医院针灸部;300381 天津,国家中医针灸临床医学研究中心
  • 收稿日期:2025-01-11 出版日期:2025-11-15
  • 通信作者: 孟智宏
  • 基金资助:
    国家自然科学基金项目(82505737); 天津科技计划项目(24ZYJDSY00260); 天津市教委科研计划项目(2021KJ142); 天津中医药重点领域科研项目(2023011); 国家中医针灸临床医学研究中心开放课题(NCRCOP2023003,NCRCOP2024001,NCRCOP2024014); 天津中医药大学第一附属医院 “拓新工程”基金(院2020041,院XB2024002)

Research on multi-omics mechanisms of acupuncture intervention in post-stroke aphasia: progress and prospects

Shizhe Deng, Bifang Zhuo, Shangkun Si, Chun Sun, Zhihong Meng()   

  1. Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
  • Received:2025-01-11 Published:2025-11-15
  • Corresponding author: Zhihong Meng
引用本文:

邓士哲, 卓碧芳, 司尚坤, 孙淳, 孟智宏. 针刺干预卒中后失语的多组学机制研究:进展与展望[J/OL]. 中华针灸电子杂志, 2025, 14(04): 147-152.

Shizhe Deng, Bifang Zhuo, Shangkun Si, Chun Sun, Zhihong Meng. Research on multi-omics mechanisms of acupuncture intervention in post-stroke aphasia: progress and prospects[J/OL]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2025, 14(04): 147-152.

卒中是全球范围内致残和致死的主要病因之一,约三分之一卒中患者遗留失语症状,针刺疗法在改善此类语言功能障碍方面展现出独特优势。其病理机制涉及脑结构功能损伤与神经炎症反应的双重作用,多组学技术的引入为机制研究提供了系统性研究工具。蛋白质组学可识别神经重塑关键差异蛋白,代谢组学能调节机体代谢网络,多模态神经影像组学可多维度揭示针刺对大脑功能的调节作用。未来研究应聚焦三大方向:开展多中心临床试验验证疗效稳定性;结合人工智能深度整合多组学数据,构建机制预测模型;开发基于生物标志物的个性化治疗及多疗法协同方案,以推动临床转化应用。

Stroke is one of a leading global cause of disability and mortality, with approximately one-third of survivors experiencing residual aphasia. Acupuncture therapy has shown unique advantages in improving such language function dysfunction. Its pathophysiological mechanisms involve the dual effects of structural and functional brain damage and neuroinflammatory responses.The introduction of multi-omics technologies provides a systematic research tool for mechanism studies: proteomics can identify key differential proteins in neural remodeling, metabolomics can regulate the body's metabolic network, and multimodal neuroimaging omics can reveal the regulatory effects of acupuncture on brain function from multiple dimensions. Future research should focus on three directions: conducting multi-center clinical trials to verify the stability of therapeutic effects; deeply integrating multi-omics data with artificial intelligence to construct mechanism prediction models; and developing biomarker-based personalized treatments and multi-therapy synergistic schemes to promote clinical translation and application.

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