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中华针灸电子杂志 ›› 2018, Vol. 07 ›› Issue (01) : 15 -20. doi: 10.3877/cma.j.issn.2095-3240.2018.01.006

所属专题: 文献

综述

针刺治疗偏头痛fMRI机制研究进展
颜铭航1, 蔡依妏1, 裴建1,()   
  1. 1. 200032 上海中医药大学附属龙华医院针灸科
  • 收稿日期:2017-12-13 出版日期:2018-02-15
  • 通信作者: 裴建
  • 基金资助:
    上海市科委科研重点项目(14401971300; 1640197030); 上海市卫计委重点项目(ZY3-CCCX-1-1007); 上海市卫计委针灸特色诊疗项目(ZJ2016001)

Research progress of fMRI study on acupuncture treatment in migraine

Minhang Gan1, Yiwen Tsai1, Jian Pei1,()   

  1. 1. Department of Acupuncture, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2017-12-13 Published:2018-02-15
  • Corresponding author: Jian Pei
  • About author:
    Corresponding author: Pei Jian, Email:
引用本文:

颜铭航, 蔡依妏, 裴建. 针刺治疗偏头痛fMRI机制研究进展[J/OL]. 中华针灸电子杂志, 2018, 07(01): 15-20.

Minhang Gan, Yiwen Tsai, Jian Pei. Research progress of fMRI study on acupuncture treatment in migraine[J/OL]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2018, 07(01): 15-20.

偏头痛是发病率较高的中枢神经系统性疾病,可严重影响患者的生活质量。文章通过对PubMed、MEDLINE、Cochrane、中国知网和维普等数据库,近10年国内外功能性磁共振成像(fMRI)观察偏头痛的针刺治疗机制研究相关文献进行检索,共纳入8篇文献。fMRI研究结果显示针刺治疗可以对偏头痛患者失调的三叉神经痛觉通路、前额顶网络、默认模式网络、下行疼痛调节机制、疼痛矩阵或疼痛调节相关脑区进行调节,达到治疗作用。对8篇临床研究所纳入的对象与对照的选择、扫描时点、fMRI分析方法、穴位选择、研究结果分析等方面对所纳入研究进行分析、总结,以期为进一步研究的开展提供可靠的循证依据与新思路。

Migraine, a central nervous system disease with high prevalence, can severely disrupt the quality of migraineurs′ life. In this review, 8 papers were included through searching published literature on fMRI studies over the past ten years on acupuncture treatment in migraine in PubMed, MEDLINE, COCHRANE, CNKI, VJIP databases. The results show that acupuncture therapy can regulate the altered brain areas in migraine patients, such as trigeminal nerve pain pathway, frontoparietal network, default mode network, descending pain modulatory system, pain matrix, or pain regulation related brain areas. The selection of subjects and control groups, scanning time points, fMRI analyzing methods, selection of acupuncture points, and study results in 8 papers were analyzed and summarized, which will provide new ideas and evidences for further research.

表1 偏头痛的fMRI针刺治疗文献资料
作者(年份) 穴位 针刺组 对照组 扫描时点 分析方法
Li,et al. (2017)[10] 治疗组1阳陵泉(GB34)、丘墟(GB40)和外关(SJ5) MwoA 11例VA1、11例VA2、13例VA3 MwoA11例SA、16例(WT) 两组:治疗4周后和治疗8周后 ALFF
治疗组2膝阳关(GB33)、地五会(GB42)和三阳络(SJ8)
治疗组3足三里(ST36)、冲阳(ST42)和偏历(L16)
Li, et al. (2017)[11] 治疗组1阳陵泉(GB34)、丘墟(GB40)和外关(SJ5) MwoA 12例VA1、14例VA2、15例VA3 MwoA13例SA、18例WT 两组:治疗4周后和治疗8周后 ICA定楔前叶为种子点楔前叶为种子点的SBA
治疗组2膝阳关(GB33)、地五会(GB42)和三阳络(SJ8)
治疗组3足三里(ST36)、冲阳(ST42)和偏历(L16)
Li, et al. (2015)[13] 治疗组1阳陵泉(GB34)、丘墟(GB40)和外关(SJ5) MwoA 11例VA1、11例VA2、13例VA3 MwoA11例SA、16例(WT) 两组:治疗4周后和治疗8周后 PAG为种子点的SBA
治疗组2膝阳关(GB33)、地五会(GB42)和三阳络(SJ8)
治疗组3足三里(ST36)、冲阳(ST42)和偏历(L16)
刘宏伟,等(2016)[12] 足临泣 15例MwoA 13例HC 两组:受试者针刺前30 min静息态扫描,进针时、进针后留针10 s,平补平泻捻转1 min,留针8 min后出针连续扫描 AAL模板获得脑区时间曲线,Pearson相关分析
Zhang, et al.(2015)[14] 双侧丝竹空(SJ23) 、率谷(GB8)、风池(GB20)、太阳(EX-HN5)、合谷(LI4)、太冲(LR3)外关(SJ5)、阳陵泉(GB34)和足临泣(GB41) 12例MwoA 12例HC 治疗组:治疗前和治疗后(4周为1个疗程)对照组:未经干预的1次扫描 ICA
Li, et al.(2015)[15] 双侧丝竹空(SJ23) 、率谷(GB8)、风池(GB20)、太阳(EX-HN5)、合谷(LI4)、太冲(LR3)外关(SJ5)、阳陵泉(GB34)和足临泣(GB41) 12例MwoA 12例HC 两组:治疗4周后和治疗8周后 ICA定ROI,进行DTI分析
Zhao, et al.(2014)[16] 治疗组(风池GB20、外关SJ5、阳陵泉GB34、丘墟GB40);对照组(耳禾髎SJ22、大陵PC7、光明GB37和太白SP3) 20例active针刺MwoA组 20例inactive针刺MwoA 两组:治疗前和治疗后(8周) ReHo
林磊,等(2013)[17] 风池、百会和行间 15例MwoA 15例头痛患者 两组:治疗前和治疗后(5 d) MRS(NAA/Cr;Cho/Cr)
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