| ［1］ |
Arvidsson A，Collin T，Kirik D，et al.Neuronal replacement from endogenous precursors in the adult brain after stroke［J］.Nat Med，2002，8（9）：963-970.
|
| ［2］ |
Takahiro T，Oberheim N，Cotrina ML，et al.Astrocytes and ischemic injury［J］.Stroke，2009，40（3 Suppl）：S8-12.
|
| ［3］ |
Ding S.Ca2+signaling in astrocytes and its role in ischemic stroke［J］.Adv Neurobiol，2014（11）：189-211.
|
| ［4］ |
Zamanian JL，Xu L，Foo LC，et al.Genomic analysis of reactive astrogliosis［J］.J Neurosci，2012，32（18）：6391-6410.
|
| ［5］ |
Li H，Zhang N，Sun G，et al.Inhibition of the group I mGluRs reduces acute brain damage and improves longterm histological outcomes after photothrombosis-induced ischaemia［J］.ASN Neuro，2013，5（3）：195207.
|
| ［6］ |
Ronaldson PT，Davis TP.Blood-brain barrier integrity and glial support：mechanisms that can be targeted for novel therapeutic approaches in stroke［J］.Curr.Pharm Des，2012，18（25）：3624-3644.
|
| ［7］ |
Wang L，Deng S，Lu Y，et al.Increased inflammation and braininjury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice［J］.Neurosci ence，2012，220（38）：100-108.
|
| ［8］ |
Nardai S，Dobolyi A，P á l G，et al.Selegiline promotesNOTCH-JAGGED signaling in astrocytes of the peri-infarct region and improves the functional integrity of the neurovascular unit in a rat model of focal ischemia［J］.Restor Neurol Neurosci，2015，33（1）：1-14.
|
| ［9］ |
Dienel GA.Fueling and imaging brain activation［J］.ASN Neuro，2012，4（5）：267-320.
|
| ［10］ |
Bolaños JP，Almeida A，Moncada S.Glycolysis：a bioenergetic or a survival pathway［J］.Trends Biochem Sci，2010，35（3）：145-149.
|
| ［11］ |
Chuquet J，Quilichini P，Nimchinsky EA，et al.Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex［J］.J Neurosci，2010，30（45）：15298-15303.
|
| ［12］ |
Bittner CX，Loaiza A，Ruminot I，et al.High resolution measurement of the glycolytic rate［J］.Front Neuroenergetics，2010，2（26）：1-11.
|
| ［13］ |
Schurr A，Payne RS.Lactate，not pyruvate，is neuronal aerobic glycolysis end product：an in vitro electrophysiological study［J］.Neuroscience，2007，147（3）：613-619.
|
| ［14］ |
Marcoux J，McArthur DA，Miller C，et al.Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury［J］.Crit Care Med，2008，36（10）：2871-2877.
|
| ［15］ |
Szydlowska K，Tymianski M.Calcium，ischemia and excitotoxicity［J］.Cell Calcium，2010，47（2）：122-129.
|
| ［16］ |
Bardehle S，Kr ü ger M，Buggenthin F，et al.Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation［J］.Nat Neurosci，2013，16（5）：580586.
|
| ［17］ |
Sirko S，Behrendt G，Johansson PA，et al.Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog.［corrected］［J］.Cell Stem Cell，2013，12（4）：426-439.
|
| ［18］ |
Moore DL，Jessberger S.All astrocytes are not created equal-the role of astroglia in brain injury［J］.EMBO Rep，2013，14（6）：487-488.
|
| ［19］ |
Jiang P，Chen C，Wang R，et al.hESC-derived Olig2+progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury［J］.Nat Commun，2013（4）：2196.
|
| ［20］ |
Ding S.Dynamic reactive astrocytes after focal ischemia［J］.Neural Regen Res，2014，9（23）：2048-2052.
|
| ［21］ |
Shimada IS，LeComte MD，Granger JC，et al.Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke［J］.J Neurosci，2012，32（23）：7926-7940.
|
| ［22］ |
Su Z，Niu W，Liu ML，et al.In vivo conversion of astrocytes to neurons in the injured adult spinal cord［J］.Nat Commun，2014（5）：3338-3353.
|
| ［23］ |
Guo Z，Zhang L，Wu Z，et al.In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimers disease model［J］.Cell Stem Cell，2014，14（2）：188-202.
|
| ［24］ |
Laywell ED，Rakic P，Kukekov VG，et al.Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain［J］.Proc Natl Acad Sci U S A，2000，97（25）：13883-13888.
|
| ［25］ |
Imayoshi I，Kageyama R.bHLH Factors in Self-Renewal，Multipotency，and Fate Choice of Neural Progenitor Cells［J］.Neuron，2014，82（1）：9-23.
|
| ［26］ |
Mart í nez-Cerdeño V，Noctor SC，Espinosa A，et al.Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats［J］.Cell Stem Cell，2010，6（3）：238-250.
|