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中华针灸电子杂志 ›› 2013, Vol. 02 ›› Issue (06) : 280 -285. doi: 10.3877/cma.j.issn.2095-3240.2013.06.003

综述

血脑屏障损伤和阿尔茨海默病
高靓1, 张雪竹1,()   
  1. 1.300193 天津中医药大学第一附属医院
  • 收稿日期:2013-09-30 出版日期:2013-12-15
  • 通信作者: 张雪竹
  • 基金资助:
    国家自然科学基金资助项目(81202739)教育部博士点课题(20111210120004)

Blood-brain barrier dysfunction and Alzheimer's disease

Liang GAO1, Xue-zhu ZHANG1,()   

  1. 1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China
  • Received:2013-09-30 Published:2013-12-15
  • Corresponding author: Xue-zhu ZHANG
引用本文:

高靓, 张雪竹. 血脑屏障损伤和阿尔茨海默病[J/OL]. 中华针灸电子杂志, 2013, 02(06): 280-285.

Liang GAO, Xue-zhu ZHANG. Blood-brain barrier dysfunction and Alzheimer's disease[J/OL]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2013, 02(06): 280-285.

血脑屏障(BBB)结构和功能正常是维持中枢神经组织内环境稳定的保证。 BBB 清除β 淀粉样蛋白障碍会导致其在血管周围堆积,造成BBB 通透性增加,诱发脑出血,引起氧化损伤、慢性炎症等病理过程,恶化神经退行性病变的进程。 此外,动脉粥样硬化也是造成BBB 损伤的重要原因,并与阿尔茨海默病(AD)认知下降关系密切。目前对BBB 功能异常在AD 发生发展中扮演的角色还存在争议。尽快开展相关前瞻性研究,阐明BBB 损伤与AD 的关系,寻找有效的干预措施,是防治AD 的当务之急。

The normal structure and function of blood-brain barrier(BBB)is necessary to maintain homeostasis within the central nervous system. The β-amyloid(Aβ)cannot be cleared efficiently from brain and is accumulated in perivascular spaces due to BBB impairment,which can further induce the increased permeability of BBB,cerebral hemorrhage,oxidative damage,chronic inflammation and other pathological processes,and then accelerate the process of neurodegeneration. In addition,atherosclerosis is also an important reason causing BBB damage,and which is closely related to the cognitive decline in Alzheimer's disease(AD). At present,there is still controversy over the role of BBB dysfunction in the development of AD. Therefore,further studies need to be carried out as soon as possible to clarify the relationships between BBB injury and AD,and to find effective treatments for AD.

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