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中华针灸电子杂志 ›› 2012, Vol. 01 ›› Issue (01) : 21 -24. doi: 10.3877/cma.j.issn.2095-3240.2012.01.006

综述

细胞骨架与神经退行性疾病相关性研究进展
聂坤1   
  1. 1. 300193 天津中医药大学第一附属医院
  • 收稿日期:2012-02-21 出版日期:2012-08-15
  • 基金资助:
    国家自然基金(编号:81072882)

Progress of research on the correlation between cytoskeleton and neurodegenerative diseases

Kun NIE1   

  1. 1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine ,Tianjin 300193,China
  • Received:2012-02-21 Published:2012-08-15
引用本文:

聂坤. 细胞骨架与神经退行性疾病相关性研究进展[J/OL]. 中华针灸电子杂志, 2012, 01(01): 21-24.

Kun NIE. Progress of research on the correlation between cytoskeleton and neurodegenerative diseases[J/OL]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2012, 01(01): 21-24.

阿尔兹海默症最主要的细胞病理变化,是细胞外淀粉样蛋白沉积形成的老年斑以及细胞内细胞骨架异常交联形成的神经纤维缠结。其他常见神经退行性疾病,如杭廷顿症、帕金森症中,也出现与细胞骨架结构相关的特征性病理变化。提示细胞骨架结构是神经退行性疾病共同的发病关键环节。从细胞骨架结构的角度认识神经退行性疾病发病的分子机制,对全面认识这类疾病的生物学机制很有帮助。综述近年细胞骨架相关的神经退行性疾病的分子机制研究进展,从细胞骨架结构以及相关细胞信号通路进行分析,总结以细胞骨架为靶点治疗神经退行性疾病的新发现。

The histopathological hallmarks of Alzheimer's disease are the extracellular amyloid plaques, and the intracellular neurofibrillary tangles, composed of paired helical filaments of the microtubule-associated protein. The same histopathological hallmarks relating to cytoskeleton as Alzheimer disease were found in the other neurodegenerative disease including Huntington's disease and Parkinson's disease, These suggest cytoskeletal pathologies maybe play an important role in neurodegenerative disease.cognition about the molecular mechanism of neurodegenerative diseases on the base of cytoskeleton structures,which was very helpful to understand comprehensivelythe mechanism of the disease. Here we review new findings about these cytoskeletal pathologies in neurodegenerative disease, and emphasize the role of cytoskeletal structures and the associated cellar signaling. We also review new findings about the treatment of neurodegenerative disease using cytoskeleton as a target.

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