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Chinese Journal of Acupuncture and Moxibustion(Electronic Edition) ›› 2014, Vol. 03 ›› Issue (03): 120-123. doi: 10.3877/cma.j.issn.2095-3240.2014.03.005

• Reviews • Previous Articles     Next Articles

Progress of telomerase 1 in cancer treatment

Chong Li1,(), Xu Zheng1   

  1. 1.Department of Pathology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China
  • Received:2014-01-22 Online:2014-06-15 Published:2024-11-28
  • Contact: Chong Li

Abstract:

Tankyrase 1(TNKS 1)can maintain the telomere length by modifying telomere-binding protein glycosylation, leading tumorigenesis. In many cancers, TNKS 1 protein was expressed at high levels. Tankyrase inhibitors have anti-tumor activity. The small molecule tyrosine kinase inhibitors can induce the β-catenin degradation and antagonizing Wnt signaling by stabilizing protein expression,restraining tumor growth. Many biological processes and the pathogenic process of Wnt signal system are regulated by TNKS 1 and TNKS 1 inhibitors. In addition, the combined use of TNKS 1 inhibitors with other inhibitors can shorten the time of necrosis and apoptosis of tumor cells. Recent research offers insights into the role of TNKS 1 and TNKS 1 inhibitors in maintaining telomere dynamic balance and regulating the Wnt/β-catenin pathway, which may hold promise for cancer therapy. This article reviews the bionomics of TNKS 1 and new type specific inhibitor of TNKS 1 and discusses its current application in clinic cancer therapy.

Key words: Tankyrases, Signal transduction, Neoplasms

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