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Chinese Journal of Acupuncture and Moxibustion(Electronic Edition) ›› 2013, Vol. 02 ›› Issue (06): 280-285. doi: 10.3877/cma.j.issn.2095-3240.2013.06.003

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Blood-brain barrier dysfunction and Alzheimer's disease

Liang GAO1, Xue-zhu ZHANG1,()   

  1. 1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China
  • Received:2013-09-30 Online:2013-12-15 Published:2024-11-27
  • Contact: Xue-zhu ZHANG

Abstract:

The normal structure and function of blood-brain barrier(BBB)is necessary to maintain homeostasis within the central nervous system. The β-amyloid(Aβ)cannot be cleared efficiently from brain and is accumulated in perivascular spaces due to BBB impairment,which can further induce the increased permeability of BBB,cerebral hemorrhage,oxidative damage,chronic inflammation and other pathological processes,and then accelerate the process of neurodegeneration. In addition,atherosclerosis is also an important reason causing BBB damage,and which is closely related to the cognitive decline in Alzheimer's disease(AD). At present,there is still controversy over the role of BBB dysfunction in the development of AD. Therefore,further studies need to be carried out as soon as possible to clarify the relationships between BBB injury and AD,and to find effective treatments for AD.

Key words: Blood-brain barrier, Alzheimer disease, Amyloid

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