Abstract:

Brain-gut axis imbalance is an important cause of simple obesity, and the activation of immune inflammatory factors is the key link of brain-gut axis imbalance. TLR5/REG3γ signal pathway plays a key role in the occurrence and development of immune response, therefore, acupuncture is an important focus for the intervention of this signaling pathway. Acupoint catgut embedding has been widely used to treat simple obesity in clinical practice, and its effectiveness has been recognized, which is the product of the successful combination of traditional Chinese medicine theory and modern brain-gut axis theory. By organizing the main mechanism of acupoint catgut embedding in the treatment of simple obesity, including the etiology and pathogenesis of traditional Chinese medicine, intestinal immune response and the regulation of TLR5/REG3γ signal pathway, a new scientific research approach is proposed for the treatment of simple obesity through acupoint catgut embedding, which combined with the positive effects of acupuncture on inhibiting TLR genes and increasing REG3γ gene expressions. It is expected to provide reference basis for future relevant research.

Key words: Obesity, Catgut embedment in acupoint therapy, Brain-gut axis